Coenzyme
NAD+
Redox Coenzyme, Studied in Energy Metabolism
Flat $35 tracked shipping1000mg per vial
$150 USD
Add 2 more, unlock 19%
Shipping, delivery and guarantee terms
- Shipping
- Flat $35, tracked worldwide to supported markets
- Delivery
- 5 to 10 business days, guaranteed
- Payment
- Card, bank transfer, or crypto · All sales final except a purity failure
- Included
- 60-day money-back guarantee · Third-party batch COA
The short answer
What is NAD+?
NAD+ is nicotinamide adenine dinucleotide, a coenzyme present in every cell and one of the oldest molecules in biochemistry. It has two jobs in the published account. The first is redox: it shuttles electrons between the reactions that release energy from fuel, cycling between an oxidized and a reduced form without being used up. The second is as a consumed substrate, because sirtuins and PARP enzymes cleave NAD+ as part of their normal signaling, which ties the coenzyme's supply to those pathways (Covarrubias et al., 2021). Reviews of NAD+ metabolism describe tissue levels falling with age, which is the observation that turned a textbook cofactor into a research target (Covarrubias et al., 2021; Rajman et al., 2018). Peptara supplies research-grade NAD+ as a lyophilized 1000mg vial for laboratory research; this page describes what published reviews report, not an effect in any person, and a qualified clinician is the only place a personal question belongs.
The Science
A Cofactor That Is Also a Currency
Most cofactors are recycled. NAD+ is recycled for its redox work and spent for its signaling work, and that second role is what makes its supply a variable rather than a constant. The published literature is built around that distinction.
Redox Carrier
Cycles between oxidized and reduced forms, carrying electrons through energy metabolism.
Signaling Substrate
Cleaved rather than returned by sirtuins and PARP enzymes, so those pathways draw on the pool.
Falls With Age
Reviews describe tissue levels declining over time across model systems.
Applications
Common Research Areas
Energy Metabolism
The redox role in the reactions that release energy from fuel is the best established part of the record.
Sirtuin Biology
Sirtuins consume NAD+, so the coenzyme appears throughout that literature as a dependency.
DNA Damage Response
PARP enzymes also cleave NAD+, which is why DNA repair work touches the same pool.
Age-Related Decline
The reported fall in tissue levels with age is the research area, not a demonstrated intervention.
Naming
NAD+, NMN and NR: what the names mean
These three are routinely treated as interchangeable and they are not. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are intermediates in the salvage pathway that builds NAD+. They are precursors. NAD+ is the coenzyme itself, the molecule the redox and signaling reactions actually use. Yoshino and colleagues set the two apart explicitly, reviewing the biology of the intermediates as their own subject with their own evidence base (Yoshino et al., 2018).
The distinction matters when reading a study. A trial of NR is a trial of a precursor and its absorption, conversion and downstream effect; it is not a direct measurement of NAD+ itself. What ships here is NAD+ as a lyophilized 1000mg vial, so papers about NMN or NR describe a related molecule rather than this one, and this page does not borrow their results.
Evidence
How strong is the NAD+ evidence?
The mechanistic account is well established. NAD+ metabolism, the enzymes that consume it, and the reported decline in tissue levels with age are all covered in detail in the review literature (Covarrubias et al., 2021). That is the settled part.
The unsettled part is whether raising NAD+ changes an outcome. Rajman and colleagues reviewed the in vivo evidence for NAD-boosting molecules and were explicit about the shape of it: substantial animal work, and a human record that is smaller and earlier than the attention the field receives (Rajman et al., 2018). This page reports that gap rather than writing over it. No result here is an outcome claim, and nothing on this page is medical advice.
The certificate for this batch is pending. Fourteen of the nineteen catalog SKUs carry a published third-party panel today, listed on the certificates page, and the remaining five say pending rather than showing a figure no lab has measured.
Research Timeline
What the reviews describe, step by step
Research Timeline
What the reviews describe, step by step
Research timeline
What the reviews describe, step by step
The coenzyme
NAD+ is nicotinamide adenine dinucleotide, a redox coenzyme that carries electrons through the reactions of energy metabolism in every cell (Covarrubias et al., 2021).
The second job
It is also consumed as a substrate rather than only recycled: sirtuins and PARP enzymes cleave NAD+ as part of their normal signaling, which links its supply to those pathways (Covarrubias et al., 2021).
The decline
Published reviews describe tissue NAD+ falling with age across model systems, which is why the coenzyme became a longevity research target at all (Covarrubias et al., 2021; Rajman et al., 2018).
The open question
Rajman and colleagues reviewed the in vivo evidence for NAD-boosting molecules and set out what animal work has shown against what human work has not yet settled (Rajman et al., 2018).
Your Kit
What's Included
$150 USD
Flat $35 shipping · All sales final
NAD+ 1000mg Vial
1000mg per vial · Lyophilized powder, sealed vial
Research Reference
The published reviews this page cites, listed with their DOIs
Worldwide Shipping
5 to 10 business days, guaranteed
Ongoing order support
Direct team access
Your kit includes the vials and bacteriostatic water. Insulin syringes ship to select delivery regions; where they can't ship, we send a same-day sourcing link. A printed reference guide ships with every order.
Traveling with your order
Freeze-dried vials travel well; reconstituted vials travel cold. Rules vary by country. Share your dates when you order.
Why your vials arrive plain
Unlabeled on purpose: discreet, and standard for research-grade material. Match a batch to its certificate with your order number. See the COA page.
Our Guarantee
We Stand Behind Our Quality.
Peptara Labs supplies research-grade NAD+, third-party tested with a Certificate of Analysis on every batch. The guarantee is on the material and on how the order is handled. It is not a guarantee of any outcome.
60-Day Money Back Guarantee
Test it at any lab, or your money back
Send any vial to an independent lab within 60 days of delivery. If it does not test as stated on its certificate of analysis (COA), or your order was not handled correctly, you get a full refund. The 60 days is your window to verify us, not a shelf life. The guarantee is on product quality, never on a health outcome.
Study Protocol Reference, Included
Every order includes a written reference to the dose ranges published studies used, with the study named, plus support at no extra cost. This is not a prescription; consult a licensed physician.
Direct WhatsApp Access
Every order includes direct access to our support team. Questions about certificates, reconstitution, storage, shipping or an order, message us any time and a real person responds.
400+
Customers served
Consistently rated by our customers
Quality guarantee: full refund on any purity failure. All sales otherwise final. The 60-day money back guarantee covers product purity, certificate of analysis, and fulfillment. It is not conditioned on any outcome and does not promise one. This is educational information, not medical advice; consult a licensed physician.
Research and citations
Peer-reviewed sources
- Covarrubias AJ, et al. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. doi.org/10.1038/s41580-020-00313-x
- Rajman L, Chwalek K, Sinclair DA. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism. doi.org/10.1016/j.cmet.2018.02.011
- Yoshino J, Baur JA, Imai SI. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism. doi.org/10.1016/j.cmet.2017.11.002
Citations refer to the peer-reviewed publications these figures are taken from. Every dose range reported on this site is the range a named study used. Not a substitute for medical advice.
Explore more
Related guides, comparisons, and compounds studied for related endpoints
MOTS-c
Mitochondrial-derived peptide studied for cellular energy signaling.
SS-31 (Elamipretide)
Cardiolipin-binding peptide studied for mitochondrial membrane function.
Humanin
Another mitochondrial-derived peptide in the research literature.
Best peptides for energy
Where the energy-metabolism compounds sit relative to each other.
Best peptides for longevity
The longevity research area and the compounds studied in it.
Certificates of Analysis
Published third-party batch certificates and what each panel measures.
Peptara FAQ
Sourcing, COAs, cold-chain, and payment questions answered.
About Peptara
Who we are and how we source and test.
Research stacks
Five named stacks grouped by research area, each at 35% off combined retail.
NAD+ FAQ
Interested in NAD+?
Order NAD+ today. Worldwide shipping, 5 to 10 business days, guaranteed.
Order NowCertificate of analysis included · Order support on WhatsApp · Tracked worldwide shipping