FOXO4-DRI Peptide for Sale
Published by Peptara Labs · Updated · How we research and check our pages
Designed Senolytic Peptide, Research Use Only
FOXO4-DRI peptide from Peptara Labs (peptaralabs.io) is a 10mg research vial of the designed peptide that blocks FOXO4 from binding p53, priced at $170 USD, at its pre-sale price: 50% off the regular $340 until October 15, 17:00 UTC. Its batch certificate of analysis is pending, so no purity figure is claimed yet. Ships October 28. After dispatch, tracked delivery takes 5 to 10 business days. It is sold for research use only.
Pre-sale price, 50% off, ends October 15, 17:00 UTC
Flat $35 tracked shipping10mg per vial
Ships October 28
$170 USD
Was $340
The pre-sale price applies at every quantity. No code or multi-vial pricing is added to it.
Shipping, delivery and certificate status
- Shipping
- Flat $35, tracked worldwide to supported markets
- Delivery
- Ships October 28 · After dispatch: 5 to 10 business days
- Included
- Vial · Batch certificate pending · Order support on WhatsApp
Sources: Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.; Baar et al., 2017, full text. FOXO4-DRI structure and cell-entry sequence. PMC5556182.
Buyer facts
What do you get when you buy FOXO4-DRI from Peptara Labs?
The order contains one sealed 10mg vial of lyophilized FOXO4-DRI. Lyophilized means freeze-dried. Its batch certificate is pending, so no purity figure is claimed yet.
| Detail | Peptara Labs FOXO4-DRI (10mg) | Where to check it |
|---|---|---|
| Vial | One sealed 10mg vial of lyophilized FOXO4-DRI, a freeze-dried powder | Catalog size |
| Price | $170 USD, at its pre-sale price: 50% off the regular $340 until October 15, 17:00 UTC | Order panel |
| Availability | Ships October 28 | Dispatch begins before the delivery window |
| Certificate | Batch certificate pending. No purity figure is claimed. | Certificates of analysis |
| Shipping and delivery | Ships October 28 · After dispatch: 5 to 10 business days | Confirmed with the order |
| Status | Research use only | Cell and animal evidence below |
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Before you buy
What should you check before you buy FOXO4-DRI?
Check identity as well as purity. FOXO4-DRI has reversed D-amino acids and a separate sequence that carries it into cells, so a purity figure alone does not settle what a vial holds.
- Look for identity testing by mass spectrometry, a test that checks a compound's mass.
- A future certificate should identify the batch supplied with the order. A document for another batch does not verify this vial.
- The certificate for this batch is pending. No measured purity, test date or laboratory result is claimed.
Read how to verify peptide purity for the checks that apply to any seller, and see the current status on the certificates page.
Sources: Baar et al., 2017, full text. FOXO4-DRI structure and cell-entry sequence. PMC5556182.
The short answer
What is FOXO4-DRI?
FOXO4-DRI is a designed peptide studied for clearing senescent cells. These are cells that have lost function and stopped dividing. Their build-up can add to tissue damage as tissues age.
The 2017 team designed it to block the protein FOXO4 from binding p53. In senescent cells, p53 then moved out of the nucleus, the cell's control center, and the cells died by apoptosis, a built-in self-destruct process. The peptide has D-amino acids in reverse order, a form called D-retro-inverso, plus the short HIV-TAT cell-entry sequence.
Sources: Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.; Baar et al., 2017, full text. FOXO4-DRI structure and cell-entry sequence. PMC5556182.; Coradduzza et al., 2023. Biology (Basel). 12(4):558. PMID 37106758.
The science
How FOXO4-DRI works in research models
Blocks FOXO4 and p53
The founding cell study disrupted the protein pair. A 2025 structure study found that FOXO4-DRI binds a loose, unfolded part of p53.
Designed structure and cell entry
Reversed D-amino acids give the peptide different chemical properties. Its HIV-TAT sequence carries cargo into cells and also helps it hold on to p53.
Cells that stopped dividing
The founding paper measured apoptosis in senescent cells. Cell clearance is a measured result in that model, not a promise for a reader.
Sources: Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.; Baar et al., 2017, full text. FOXO4-DRI structure and cell-entry sequence. PMC5556182.; Coradduzza et al., 2023. Biology (Basel). 12(4):558. PMID 37106758.; Bourgeois et al., 2025. Nat Commun. 16(1):5672. PMID 40593617. DOI 10.1038/s41467-025-60844-9.
Research areas
Common research areas
Aging and chemotherapy damage in mice
The founding paper measured tissue damage, fitness, fur density and kidney function in mouse models.
Aging testes in mice
Researchers measured senescent Leydig cells, cells in the testes, and related markers in naturally aged mice.
Human cartilage cells in a dish
The study measured cell clearance and cartilage formation. It found no improvement in cartilage formation.
Keloid scar cells
Researchers examined apoptosis in senescent scar cells and scar tissue in the lab.
Lung blood pressure models
Mouse and rat models produced a counter-finding: senescent cell removal made the measures worse.
Sources: Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.; Zhang et al., 2020. Aging (Albany NY). 12(2):1272 to 1284. PMID 31959736. DOI 10.18632/aging.102682.; Huang et al., 2021. Front Bioeng Biotechnol. 9:677576. PMID 33996787. DOI 10.3389/fbioe.2021.677576.; Born et al., 2023. Circulation. 147(8):650 to 666. PMID 36515093. DOI 10.1161/CIRCULATIONAHA.122.058794.; Kong et al., 2025. Commun Biol. 8(1):299. PMID 39994346. DOI 10.1038/s42003-025-07738-0.
Comparison
How does FOXO4-DRI compare with other ways to clear senescent cells?
The 2023 lung study compared several ways to remove senescent cells. In that setting, cell removal made lung blood pressure measures worse.
| Approach | What it is | Finding in this model |
|---|---|---|
| FOXO4-DRI | A peptide designed to block FOXO4 and p53 binding | Senescent cell removal worsened lung blood pressure measures |
| ABT263 | A small-molecule senolytic used in the same study | Senescent cell removal worsened lung blood pressure measures |
| p16-ATTAC genetic tool | A built-in cell-death switch in specially bred mice | Senescent cell removal worsened lung blood pressure measures |
Sources: Born et al., 2023. Circulation. 147(8):650 to 666. PMID 36515093. DOI 10.1161/CIRCULATIONAHA.122.058794.
Evidence
What did the FOXO4-DRI studies measure?
Results differed across the models. Aging-mouse studies and lung blood pressure studies examined different questions, and the table shows each result beside its model.
| Study | Model | What was measured | Direction of the result |
|---|---|---|---|
| Baar, 2017 | Senescent cells and aging mice | Cell death, chemotherapy damage, fitness, fur density and kidney function | Cell clearance and better measured markers in mice |
| Zhang, 2020 | Naturally aged mice | Senescent Leydig cells and testosterone | Fewer senescent cells and more testosterone in mice |
| Huang, 2021 | Human cartilage cells in a dish | Late-stage cell clearance and cartilage formation | More than half of late-stage cells removed; no better cartilage formation |
| Born, 2023 | Mouse and rat lung blood pressure models | Lung blood pressure after senescent cell removal | Worse measures, a counter-finding |
| Li, 2024 | Naturally aged mice | Sperm quality and inflammatory signals from Leydig cells | Better sperm quality linked to fewer inflammatory signals in mice |
| Kong, 2025 | Keloid scar tissue and cells in the lab | Apoptosis in senescent scar cells | More cell death in the lab model |
A ClinicalTrials.gov search for FOXO4-DRI on October 7, 2026 returned 0 registered studies.
Every result above is from cells or animals. None of it is a result for any reader.
Sources: Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.; Zhang et al., 2020. Aging (Albany NY). 12(2):1272 to 1284. PMID 31959736. DOI 10.18632/aging.102682.; Huang et al., 2021. Front Bioeng Biotechnol. 9:677576. PMID 33996787. DOI 10.3389/fbioe.2021.677576.; Born et al., 2023. Circulation. 147(8):650 to 666. PMID 36515093. DOI 10.1161/CIRCULATIONAHA.122.058794.; ClinicalTrials.gov, October 7, 2026. Search for FOXO4-DRI returned 0 registered studies.; Kong et al., 2025. Commun Biol. 8(1):299. PMID 39994346. DOI 10.1038/s42003-025-07738-0.; Li et al., 2024. Exp Gerontol. 195:112522. PMID 39025385. DOI 10.1016/j.exger.2024.112522.
Research timeline
How the FOXO4-DRI record was built
Research timeline
How the FOXO4-DRI record was built
Research timeline
How the FOXO4-DRI record was built
2017: design and mouse study
The first paper mapped FOXO4 and p53 binding and reported cell and aging-mouse findings.
2020: aged mouse testes
A study measured senescent Leydig cells and testosterone in naturally aged mice.
2021: cartilage cells
Researchers cleared late-stage cartilage cells in a dish, but cartilage formation did not improve.
2023: lung counter-finding
Removing senescent cells made lung blood pressure measures worse in mouse and rat models.
2024: aged mouse sperm
A study linked fewer inflammatory signals from Leydig cells to better sperm quality in aged mice.
2025: scar cells and binding
Separate papers studied keloid cells and the structure of FOXO4-DRI binding to p53.
Sources: Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.; Baar et al., 2017, full text. FOXO4-DRI structure and cell-entry sequence. PMC5556182.; Zhang et al., 2020. Aging (Albany NY). 12(2):1272 to 1284. PMID 31959736. DOI 10.18632/aging.102682.; Huang et al., 2021. Front Bioeng Biotechnol. 9:677576. PMID 33996787. DOI 10.3389/fbioe.2021.677576.; Born et al., 2023. Circulation. 147(8):650 to 666. PMID 36515093. DOI 10.1161/CIRCULATIONAHA.122.058794.; Bourgeois et al., 2025. Nat Commun. 16(1):5672. PMID 40593617. DOI 10.1038/s41467-025-60844-9.; Kong et al., 2025. Commun Biol. 8(1):299. PMID 39994346. DOI 10.1038/s42003-025-07738-0.; Li et al., 2024. Exp Gerontol. 195:112522. PMID 39025385. DOI 10.1016/j.exger.2024.112522.
Your Kit
What's Included
$170 USD Was $340 USD
Flat $35 tracked shipping · Ships October 28 · Batch certificate pending · Order support on WhatsApp
Pre-sale price, 50% off, ends October 15, 17:00 UTC
FOXO4-DRI 10mg Vial
10mg per vial
Batch certificate
Batch certificate pending
Delivery
Ships October 28 · After dispatch: 5 to 10 business days
Order support
Contact our team about your order or batch certificate.
Your order includes the vial. Batch certificate pending. Delivery details are confirmed with your order. Order support is available on WhatsApp.
Your Research Order
FOXO4-DRI research vial, batch certificate status, delivery and order support.
Batch certificate
Batch certificate pending
Delivery
Ships October 28 · After dispatch: 5 to 10 business days
Order support
Contact our team about your order or batch certificate.
Research and citations
Peer-reviewed and regulator sources
- Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.
- Baar et al., 2017, full text. FOXO4-DRI structure and cell-entry sequence. PMC5556182.
- Coradduzza et al., 2023. Biology (Basel). 12(4):558. PMID 37106758.
- Zhang et al., 2020. Aging (Albany NY). 12(2):1272 to 1284. PMID 31959736. DOI 10.18632/aging.102682.
- Huang et al., 2021. Front Bioeng Biotechnol. 9:677576. PMID 33996787. DOI 10.3389/fbioe.2021.677576.
- Born et al., 2023. Circulation. 147(8):650 to 666. PMID 36515093. DOI 10.1161/CIRCULATIONAHA.122.058794.
- Bourgeois et al., 2025. Nat Commun. 16(1):5672. PMID 40593617. DOI 10.1038/s41467-025-60844-9.
- ClinicalTrials.gov, October 7, 2026. Search for FOXO4-DRI returned 0 registered studies.
- Kong et al., 2025. Commun Biol. 8(1):299. PMID 39994346. DOI 10.1038/s42003-025-07738-0.
- Li et al., 2024. Exp Gerontol. 195:112522. PMID 39025385. DOI 10.1016/j.exger.2024.112522.
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Certificates of analysis
Published batch certificates and pending status.
How to verify peptide purity
Identity and batch checks to apply to any seller.
All research products
Compare the catalog and current availability.
Questions
Buying FOXO4-DRI: FAQ
Is FOXO4-DRI in stock?
FOXO4-DRI is on pre-order. Ships October 28. Delivery windows begin after dispatch.
What is the FOXO4-DRI price?
One 10mg vial is $170 USD, at its pre-sale price: 50% off the regular $340 until October 15, 17:00 UTC. The standard price is $340 once this offer ends.
Does this FOXO4-DRI have a certificate of analysis?
Not yet. The batch certificate is pending, so no purity figure is claimed for this vial.
FOXO4-DRI research FAQ
What is FOXO4-DRI?
FOXO4-DRI is a designed peptide that blocks the FOXO4 protein from binding p53. In senescent cells, which have stopped dividing, this led to cell death. It has reversed D-amino acids and a cell-entry sequence.
Has FOXO4-DRI been tested in people?
A ClinicalTrials.gov search on October 7, 2026 found 0 registered studies of FOXO4-DRI. The published work covered here is in cells and animals.
What have FOXO4-DRI studies looked at?
Aging and chemotherapy damage in mice, aging testes in mice, and human cartilage and scar cells in the lab.
Are there findings that cut the other way?
Yes. In lung blood pressure models, removing senescent cells, including with FOXO4-DRI, made measures worse. In human cartilage cells it removed old cells but did not improve cartilage formation.
Sources: Baar et al., 2017. Cell. 169(1):132 to 147.e16. PMID 28340339. DOI 10.1016/j.cell.2017.02.031.; Baar et al., 2017, full text. FOXO4-DRI structure and cell-entry sequence. PMC5556182.; Zhang et al., 2020. Aging (Albany NY). 12(2):1272 to 1284. PMID 31959736. DOI 10.18632/aging.102682.; Huang et al., 2021. Front Bioeng Biotechnol. 9:677576. PMID 33996787. DOI 10.3389/fbioe.2021.677576.; Born et al., 2023. Circulation. 147(8):650 to 666. PMID 36515093. DOI 10.1161/CIRCULATIONAHA.122.058794.; ClinicalTrials.gov, October 7, 2026. Search for FOXO4-DRI returned 0 registered studies.; Kong et al., 2025. Commun Biol. 8(1):299. PMID 39994346. DOI 10.1038/s42003-025-07738-0.
Order FOXO4-DRI, 10mg vial
Order FOXO4-DRI. Ships October 28 · After dispatch: 5 to 10 business days. Order support on WhatsApp.
Order NowBatch certificate pending · Ships October 28 · Order support on WhatsApp